Warfarin reduced major stroke more than aspirin in elderly patients with atrial fibrillation in primary care.
نویسنده
چکیده
and commentary also appear in ACP Journal Club. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . For correspondence: Dr J Mant and Professor R Hobbs, University of Birmingham, Birmingham, UK; [email protected] Source of funding: Medical Research Council (MRC). Warfarin v aspirin for preventing stroke in patients >75 years of age with atrial fibrillation* Outcome at mean 2.7 years Warfarin Aspirin RRR (95% CI) NNT (CI) Major stroke, intracranial haemorrhage, or systemic embolism 4.9% (24/488) 9.9% (48/485) 50% (21 to 69) 21 (12 to 58) *Abbreviations defined in glossary. RRR, NNT, and CI calculated from data in article. Major stroke (4.3% v 9.1%), other intracranial haemorrhage (0.4% v 0.2%), and systemic embolism (0.2% v 0.6%).
منابع مشابه
Protocol for Birmingham Atrial Fibrillation Treatment of the Aged study (BAFTA): a randomised controlled trial of warfarin versus aspirin for stroke prevention in the management of atrial fibrillation in an elderly primary care population [ISRCTN89345269]
BACKGROUND Atrial fibrillation (AF) is an important independent risk factor for stroke. Randomised controlled trials have shown that this risk can be reduced substantially by treatment with warfarin or more modestly by treatment with aspirin. Existing trial data for the effectiveness of warfarin are drawn largely from studies in selected secondary care populations that under-represent the elder...
متن کاملWarfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial.
BACKGROUND Anticoagulants are more effective than antiplatelet agents at reducing stroke risk in patients with atrial fibrillation, but whether this benefit outweighs the increased risk of bleeding in elderly patients is unknown. We assessed whether warfarin reduced risk of major stroke, arterial embolism, or other intracranial haemorrhage compared with aspirin in elderly patients. METHODS 97...
متن کاملAntithrombotic therapy to prevent stroke in patients with atrial fibrillation.
PURPOSE To characterize the efficacy and safety of anticoagulants and antiplatelet agents for prevention of stroke in patients with atrial fibrillation. DATA SOURCES Randomized trials identified by using the search strategy developed by the Cochrane Collaboration Stroke Review Group. STUDY SELECTION All published randomized trials testing antithrombotic agents to prevent stroke in patients ...
متن کاملAnticoagulation intensity for elderly atrial fibrillation patients: should we use a conventional INR target (2.0 to 3.0) or a lower range?
Stroke prevention is of paramount importance in elderly atrial fibrillation (AF) patients, given that both age and AF independently increase the risk of stroke (1). Despite the overwhelming evidence that anticoagulation therapy with warfarin, to maintain the international normalised ratio (INR) between 2.0 and 3.0, reduces the risk of stroke compared to antiplatelet therapy (relative risk [RR] ...
متن کاملCost effectiveness of warfarin versus aspirin in patients older than 75 years with atrial fibrillation.
BACKGROUND AND PURPOSE Oral anticoagulants are effective at reducing stroke compared with aspirin in atrial fibrillation patients older than 75 years. Although the benefits of reduced stroke risk outweigh the risks of bleeding, the cost effectiveness of warfarin in this patient population has not yet been established. METHODS An economic evaluation was conducted alongside a randomized, contro...
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ورودعنوان ژورنال:
- ACP journal club
دوره 147 3 شماره
صفحات -
تاریخ انتشار 2007